Beilstein J. Org. Chem.2012,8, 1584–1593, doi:10.3762/bjoc.8.181
- andchemoselectivereaction; thionation; X-ray structure; Introduction
Imidazotriazines represent an important class of condensed heterobicycles that display a variety of significant biological activities, including anticancer [1], antimicrobial [2], anti-inflammatory [3] and neuroprotective [4
introduced. The synthetic strategy allows broad structural variation of this new drug-like heterobicyclic scaffold. In addition to extensive NMR and MS analyses, the structure of one derivative was confirmed by X-ray crystallography.
Keywords: hydantoins; hydrazides; imidazotriazines; N-alkylation; regio
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Graphical Abstract
Figure 1:
Biologically active imidazo[1,2,4]triazine scaffolds 1–4.